Cognitive, focus & mood
Semax
A synthetic peptide derived from ACTH, approved in Russia for stroke recovery and cognitive disorders.
How it works
A fragment of ACTH with three extra amino acids that make it last longer. It raises BDNF without any hormonal effect.
What it is used for
Stroke, cognitive disorders and optic-nerve disease (approved in Russia).
What the evidence says
Russian clinical studies, with little Western research.
Side effects and cautions
Irritability and trouble sleeping.
Half-life
A few minutes in blood; its effects last longer (published estimates)
Makes sense for
- Focus and cognitive support
- Stroke recovery where it is approved
Does not make sense for
- People prone to anxiety or insomnia
Boost the effect
- Aerobic exercise: raises BDNF, the same factor Semax supports
- A regular sleep schedule: Semax can make sleep lighter