Cognitive, focus & mood
PE-22-28
An experimental peptide derived from spadin, studied in animals for antidepressant-like effects.
How it works
A shortened version of spadin. It blocks the TREK-1 potassium channel, which is linked to depression.
What it is used for
Depression and mood.
What the evidence says
In mice it had a fast antidepressant-like effect. There are no human studies.
Side effects and cautions
Its safety is unknown.
Half-life
Not established in people
Makes sense for
- Mood research only
Does not make sense for
- Replacing proven treatment for depression
Boost the effect
- Daily movement and morning daylight: support mood
- A regular sleep schedule: steadies mood