Sleep & wakefulness

Orexin B

The second orexin neuropeptide, also involved in wakefulness. Mostly lab research.

How it works

The second orexin neuropeptide. It acts mainly on the OX2 receptor, which controls wakefulness.

What it is used for

Wakefulness and sleep disorders.

What the evidence says

Lab research only.

Side effects and cautions

Its safety is unknown; the same concerns as orexin A apply.

Half-life

Minutes: it is quickly broken down in blood

Makes sense for

  • Lab research only

Does not make sense for

  • Any human use: there is no human data