Longevity & cellular health
MOTS-c
A peptide encoded in mitochondrial DNA, studied in animals for metabolism and exercise capacity.
How it works
A small peptide encoded in mitochondrial DNA. It activates AMPK, helping muscle use glucose and adapt to exercise.
What it is used for
Metabolic health, exercise capacity and aging.
What the evidence says
In mice it improved insulin sensitivity and exercise capacity. A modified version has entered early human trials.
Side effects and cautions
Its safety is unknown. Injection-site reactions are common.
Half-life
Not established in people
Makes sense for
- Metabolic and exercise research
Does not make sense for
- Anyone who needs proven results
Boost the effect
- Exercise: MOTS-c acts on the same energy pathway (AMPK) that exercise switches on