Weight loss & metabolic health
Dulaglutide
A GLP-1 receptor agonist approved for type 2 diabetes (Trulicity). Taken once a week.
The label allows further steps to 3 mg and then 4.5 mg, each after at least 4 weeks, only when more blood-sugar control is needed. uPrime shows the standard 1.5 mg maintenance.
How it works
It mimics the gut hormone GLP-1: it releases insulin when blood sugar is high, lowers glucagon, slows down the stomach and reduces appetite. It lasts a full week.
What it is used for
Type 2 diabetes, and lowering the risk of heart attack and stroke in people with type 2 diabetes.
What the evidence says
Large trials (AWARD and REWIND) showed better blood-sugar control and fewer cardiovascular events. Its weight loss is smaller than with semaglutide or tirzepatide.
Side effects and cautions
Nausea, vomiting and diarrhea, mostly at the start. Rare pancreatitis and gallbladder problems. Not for people with a personal or family history of medullary thyroid cancer or MEN2.
Half-life
About 5 days (label)
Makes sense for
- Adults with type 2 diabetes, especially with heart risk
Does not make sense for
- Type 1 diabetes
- A history of pancreatitis
- Personal or family history of medullary thyroid cancer or MEN2
Boost the effect
- High-protein meals (about 1.2–1.6 g per kg of body weight a day): help keep muscle while you lose weight
- Strength training 2–3 times a week: protects muscle and strength
- Plenty of water and fiber: ease the usual constipation and nausea