Sleep & wakefulness
DSIP
Delta sleep-inducing peptide, tested in small human trials for sleep. Results have been inconsistent.
How it works
A peptide first found in rabbits during deep sleep. How it works is unclear; it may adjust stress hormones and sleep patterns.
What it is used for
Insomnia, stress and withdrawal symptoms.
What the evidence says
Small human studies from the 1980s with inconsistent results.
Side effects and cautions
Headache, nausea and grogginess.
Half-life
Not established in people
Makes sense for
- Adults with trouble sleeping or high stress
Does not make sense for
- Anyone who needs a proven insomnia treatment
Boost the effect
- No caffeine after midday and no alcohol in the evening: both disrupt deep sleep
- A dark, cool bedroom: supports deep sleep