Cognitive, focus & mood
Dihexa
An experimental compound derived from angiotensin IV, studied in animals for memory and the formation of new connections between neurons.
All data come from animal studies, the key papers were retracted, and it acts on a pathway linked to cancer growth. The protocol shown is the community reference for injection (2 mg a day); uPrime counts the shortest 4-week cycle.
How it works
Derived from angiotensin IV, it boosts the HGF/c-Met pathway, which helps form new connections between neurons. In rats it was extremely potent.
What it is used for
Alzheimer’s disease and cognitive decline.
What the evidence says
Rat studies only.
Side effects and cautions
The c-Met pathway is also involved in cancer growth, and the long-term risks are unknown.
Half-life
Not established in people
Makes sense for
- Cognitive research only
Does not make sense for
- Anyone with cancer or a family history of cancer
- Anyone who needs proven results
Boost the effect
- Aerobic exercise: raises BDNF and supports brain plasticity
- Omega-3 (DHA) from fish: a building block of brain cell membranes
- Regular, sufficient sleep: when the brain consolidates memory